Publications from the Metagenics Research and Development Department
The research team at Metagenics is on the cusp of new developments in the therapeutic applications of nutrition. As a science-based healthcare company, Metagenics takes leading positions on issues of importance in natural medicine.
Our scientists and clinicians also actively publish in recognized journals. In fact, over 200 articles from Metagenics' scientists and clinicians have appeared in peer-reviewed medical science journals.
Who's documenting the latest breakthroughs in nutrition? The scientific professionals at Metagenics!
2009
Desai A, Konda VR, Darland G, Austin M, Prabhu KS, Bland JS, Carroll BJ, Tripp ML. META060 inhibits multiple kinases in the NF-kB pathway and suppresses LPS-mediated inflammation in vitro and ex vivo. Inflamm. Res. 2009;1-6. PMID: 19169645
2008
Lerman RH, Minich DM, Darland G, Lam JJ, Schiltz B, Babish JG, Bland JS, Tripp ML. Enhancement of a modified Mediterranean-style, low glycemic load diet with specific phytochemicals improves cardiometabolic risk factors in subjects with metabolic syndrome and hypercholesterolemia in a randomized trial. Nutr Metab (Lond) 2008:5(1):29. PMID: 18983673
Minich DM, Bland Jeffrey S. Dietary management of the metabolic syndrome beyond macronutrients. Nutrition Reviews 2008;66(8):429-444.
Robledo MJ, Flynn MP. Effect of weight loss on cardiometabolic risk using a structured dietary program. J Clin Lipidology 2008;2(3);A223.
Hall AJ, Babish JG, Darland GK, Carroll BJ, Konda VR, Lerman RH, Bland JS, Tripp ML. Safety, efficacy and anti-inflammatory activity of rho iso-alpha-acids from hops. Phytochemistry 2008;69(7):1534-1547. PMID: 18358504
2007
Deanna M. Minich, Jeffrey S. Bland, Jeffrey Katke, Gary Darland, Amy Hall, Robert H. Lerman, Joseph Lamb, Brian Carroll, and Matthew Tripp. Clinical safety and efficacy of NG440: a novel combination of rho iso-alpha acids from hops, rosemary, and oleanolic acid for inflammatory conditions. Can J Physiol Pharmacol. 2007;85:872-883.
Minich DM, Bland JS. Acid–Alkaline Balance: Role in Chronic Disease and Detoxification. Altern Ther Health Med. 2007 Jul-Aug; 13(4):62-65.
Minich DM, Bland JS. A review of the clinical efficacy and safety of cruciferous vegetable phytochemicals. Nutrition Reviews. 2007;65:259-267.
Anuradha Desai, Veera Reddy Konda, Amy Hall, Jeff Bland, Matthew Tripp. Comparison of anti-inflammatory activity of two selective kinase response modulators (SKRMs), rho-iso-alpha acids (RIAA) and tetrahydro-iso-alpha acids (THIAA), in lipopolysaccharide (LPS) mediated inflammation in RAW 264.7 macrophages. The FASEB Journal . 2007;21:702. 5.
2006
Ignarro LJ, Bland JS. Editorial commentary: evaluation of the article published in JAMA (295:58-64, 2006) by Schulman et al. Review of arginine and vascular health study.
JANA Volume 9, No. 2, 2006.
Auborn KJ. Can indole-3-carbinol-induced changes in cervical intraepithelial neoplasia be extrapolated to other food components? J Nutr 2006;136(10):S2676-S78. PMID: 16988146
Rogan EG. The natural chemopreventive compound indole-3-carbinol: state of the science.
In Vivo 2006;20(2):221-28. PMID: 16634522
Dan Lukaczer, ND, DeAnn J. Liska, PhD, Robert H. Lerman, MD, Gary Darland, PhD, Barbara Schiltz, MS, RN Matthew Tripp PhD, Jeffrey S. Bland PhD, FACN. Effect of a low glycemic index diet with soy protein and phytosterols on CVD risk factors in postmenopausal women. Nutrition. 2006;22(2):104-13. PMID: 16459222
A.J. Hall, M. Tripp, T. Howell, G. Darland, J.S. Bland, J.G. Babish. Gastric mucosal cell model for estimating relative gastrointestinal toxicity of non-steroidal anti-inflammatory drugs. Prostaglandins, Leukotrienes & Essential Fatty Acids. 2006;75 (1):9-17. PMID: 16806870
Bhaskar R. Shenai, Gary Darland, Robert H. Lerman, Matthew L. Tripp, Jeffrey S. Bland. Toxicology and pharmacology of rho-iso-alpha acids (RIAA), hop-derived inhibitors of prostaglandin E2 formation. 2006 Experimental Biology meeting abstracts. The FASEB Journal: 2006;20:A1145.
Matthew Tripp, Veera Reddy Konda, Amy Hall, Anuradha Desai, Brian Carroll, Gary Darland, Robert Lerman, Dennis Emma, Jeffrey S. Bland. Rho iso-alpha acids, a modified hop (Humulus lupulus) extract, inhibits protein kinases involved in autoimmune disease. 2006 Experimental Biology meeting abstracts. The FASEB Journal: 2006;20:A1125.
Veera Reddy Konda, Amy Hall, Anuradha Desai, Brian Carroll, Gary Darland, Jeff Bland , Matthew Tripp. Anti-inflammatory mechanism of rho-iso-alpha acids from hop extract. 2006 Experimental Biology meeting abstracts. The FASEB Journal: 2006;20:A1145.
2005
Matthew Tripp, PhD, Gary Darland, PhD, Daniel Lukaczer, Jeffrey S. Bland. Hop and modified hop extracts have potent in vitro anti-inflammatory properties. Published Proceedings from 1st International Symposium on Humulus. Editors K.E. Hummer and J.A. Henning Acta Horiculturae 668, ISHS 2005.
Jeffrey S. Bland, Ph.D., FACN. The Fructose Controversy: Separating Fact from Fiction. J Am Nutraceutical Assoc. 2005; 8:1-11.
Daniel Lukaczer, ND, Gary Darland, PhD, Matthew Tripp, PhD, DeAnn Liska, PhD, Robert H. Lerman, MD, PhD, Barbara Schiltz, MS, RN, Jeffrey S Bland PhD. Clinical Effects of a proprietary combination isoflavone nutritional supplement in menopausal women: a pilot trial. Alternative Therapies. 2005;11:60-65. PMID: 16189949
Daniel Lukaczer, ND; Gary Darland, PhD; Matthew Tripp, PhD; DeAnn Liska, PhD; Robert H. Lerman, MD, PhD; Barbara Schiltz, MS, RN; Jeffrey S. Bland PhD. A pilot trial evaluating Meta050, a proprietary combination of reduced iso-alpha acids, rosemary extract, and oleanolic acid in patients with arthritis and fibromyalgia. Phytotherapy Research. 2005;19:864-69.
PMID: 16261517
Dan Lukaczer, ND. An integrative nutritional approach to the treatment of rheumatoid arthritis. Integr Med. 2005;4:16-22.
Steven Faber, MD, FACG, Scott Rigden, MD, Dan Lukaczer, ND. The use of probiotics in the treatment of irritable bowel syndrome: two case reports. Altern Ther Health Med. 2005;11:60-62.
DeAnn J Liska, Matthew Tripp, Dan Lukaczer, Robert H Lerman, Gary Darland, Barbara Schiltz, Jeffrey S Bland. Randomized cross-over study of RIAA, rosemary extract, and oleanolic acid on gastrointestinal integrity using fecal Calprotectin. 2005 Experimental Biology meeting abstracts. The FASEB Journal: Abstract #5660.
DeAnn J Liska, Robert H Lerman, Dan Lukaczer, Scott Rigden. Use of a soy-based medical food in the management of refractory obesity and insulin resistance. 2005 Experimental Biology meeting abstracts. The FASEB Journal: Abstract # 5634.
DeAnn Liska, PhD, Matthew Tripp, PhD, Dan Lukaczer, ND, Robert H Lerman, MD, PhD, Barbara Schiltz, RN, MS, Jeffrey Bland, PhD. Beneficial effects of a low-glycemic-index diet with soy protein and phytosterols on inflammation and cardiovascular risk factors in postmenopausal women. 2005 Experimental Biology meeting abstracts. The FASEB Journal: Abstract #5657.
2004
Jeffrey S. Bland, PhD, FACN, CNS: functional medicine pioneer. Altern Ther Health Med. 2004;10:74-81. PMID: 15478789
Rigden S, Lerman RH. Successful management of complicated high-risk obese patients using a comprehensive program including a soy-based medical food: case reports. Townsend Letters. 2004;July:59-62.
Lukaczer D, Lerman RH, Darland G, Liska D, Schiltz B, Tripp M, Bland JS. Benefits of a proprietary reduced iso-alpha acids (hops), rosemary extract, and oleanolic acid supplement on pain in subjects with osteoarthritis. 2004 Experimental Biology meeting abstracts. The FASEB Journal: Abstract #8463.
Lukaczer D, Lerman RH, Liska D, Schiltz B, Bland JS. Initial observations of a controlled trial comparing a soy and phytosterol beverage and dietary program with the American Heart Association (AHA) Step 1 dietary program. 2004 Experimental Biology meeting abstracts. The FASEB Journal: Abstract #8642.
Lerman RH, Lukaczer D, Darland G, Liska D, Schiltz B, Tripp M, Bland JS. Assessment of bone resorption in osteoarthritic subjects using a proprietary reduced iso-alpha acids, rosemary extract, and oleanolic acid supplement. 2004 Experimental Biology meeting abstracts. The FASEB Journal: Abstract #8582.
2003
Bland JS. Antioxidants: where we have been, where we are, and where we are going – editorial. J Am Nutraceutical Assoc. 2003;6(2):1-2.
Lukaczer D, Liska DJ. Recognizing insulin resistance syndrome. Integr Med. 2003;2(1):42-49.
Lukaczer D, Lerman RH. Allergens, dysbiosis and immune dysregulation: case studies on inflammatory bowel disease. Altern Ther Health Med. 2003;9(3):136,130-34. PMID: 12776484
Lerman RH. Nutritional approach enhances response to statins in severe hypercholesterolemic patient. Integr Med. 2003;2(2):44-47.
2002-2001
Liska DJ, Bland JS. Emerging clinical science of bifunctional support for detoxification. Townsend Letter 2002; 231:42-43.
Bland JS. Glucosamine sulfate in the treatment of osteoarthritis joint disease. Int J Integr Med.2002;Feb/March:34.
Lukaczer D, Lerman RH. Women with perimenopause symptoms using a newly formulated medical food: two case reports. Clin Pract Altern Med. 2002;3(1):46-51.
Liska DJ, Leupp LR. Estrogen Metabolism: A complex web. J Am Nutraceutical Assoc. 2002;5(3):4-14.
Liska DJ, Lukaczer D. Gut restoration and chronic disease. J Am Nutraceutical Assoc. 2002;5(4):20-33.
Rings EH, Minich DM, Vonk RJ, Stellaard F, Fetter WP, Verkade HJ. Functional development of fat absorption in term and preterm neonates strongly correlates with ability to absorb long-chain Fatty acids from intestinal lumen. Pediatr Res. 2002 Jan;51(1):57-63. PMID: 11756640
Lukaczer D. Estrogen’s two-way street. Nutrition Sci News. [Serial Online]. November 2001
Kushi LH, Cunningham JE, Hebert JR, Lerman RH, Bandera EV, Teas J. The macrobiotic diet in cancer. J Nutr. 2001;131(11 Suppl):3056S-3064S. PMID: 11694648
2000-1999
Lukaczer D, Schiltz B, Liska DJ . A pilot trial evaluating the effect of an inflammatory modulating medical food in patients with fibromyalgia. Clin Pract Altern Med. 2000;1(3):148-56.
Lukaczer D. The probiotic solution for colitis. Nutrition Sci News. 2000;494-501.
Minich DM, Havinga R, Stellaard F, Vonk RJ, Kuipers F, Verkade HJ. Intestinal absorption and postabsorptive metabolism of linoleic acid in rats with short-term bile duct ligation. Am J Physiol Gatrointest Liver Physiol. 2000;279(6):G1242-48. PMID: 11093947
Bland JS. Functional medicine approach to managing syndrome X and type 2 diabetes. Int J Integr Med. 1999;1(6):39-45.
Minich DM, Voshol PJ, Havinga R, et al. Biliary phospholipid secretion is not required for intestinal absorption and plasma status of linoleic acid in mice. Biochim Biophys Acta. 1999;1441(1):14-22. PMID:10526224
Minich DM, Kalivianakis M, Havinga R, et al. Bile diversion in rats leads to a decreased plasma concentration of linoleic acid which is not due to decreased net intestinal absorption of dietary linoleic acid. Biochim Biophys Acta. 1999;19:1438(1):111-19. PMID: 10216285
1998-1995
Bland JS. The use of complementary medicine for healthy aging. Altern Ther Health Med. 1998; 4(4):42-8. PMID: 9656500
Liska DJ. The detoxification enzyme systems. Altern Med Rev. 1998;3(3):187-98. PMID: 19630736
Bland JS. The pro-oxidant and antioxidant effects of vitamin C. Altern Med Rev. 1998;3(3):170. PMID: 9630733
Medcalf D, Liska DJ, Darland G. Medical food products for functional medicine. Food Tech Eur. 1998;March/April:20-22.
Rigden S, Barrager E, Bland JS. Evaluation of the effect of a modified enter-hepatic resuscitation program in chronic fatigue syndrome patients. J Adv Med. 1998;11(4):247-262.
Liska DJ, King M, Peterson B, Medcalf D. Antigenicity of rice protein concentrate and rice flours. J Appl Nutr. 1998;50(4):110-20.
Minich DM, Vonk RJ, Verkade HJ. Intestinal absorption of essential fatty acids under physiological and essential acid-deficient conditions. J Lipid Res. 1997;38(9):1709-21. PMID: 9323581
Bland JS. Phytonutrition, phytotherapy, and phytopharmacology. Altern Ther Health Med. 1996;2(6):73-6. PMID: 8942046
Bland JS. The beta-carotene controversy in perspective. J Appl Nutr. 1996;48(1&2):42-45.
Siguel EN, Lerman RH. Prevalence of essential fatty acid deficiency in patients with chronic gastrointestinal disorders. Metabolism. 1996;45(1):12-23. PMID: 8544768
Bland JS. Guest editorial: beta-carotene controversy. J Advancement Med. 1996;9(2):91-94.
Bland JS , Barrager E, Redy RG, Bland K. A medical food-supplemented detoxification program in the management of chronic health problems. Altern Ther Health Med. 1995;1(5):62-71. PMID: 9359760
Bland JS . Oxidants and antioxidants in clinical medicine: past, present and future potential. J Nutr Environ Med. 1995;5:255-80.